Project A4 (PIs Traulsen, Schulenburg) aims to study the role of multilevel selection and microbial transmission mode in shaping host-microbiome interactions, the resulting phenotypes, and the fitness of hosts and associated microbes. The project will combine theoretical models and computer simulations with experimental evolution of the nematode model host C. elegans, for which the selection on the higher level can be controlled and microbial transmission mode can be experimentally manipulated.
A4
Evolution and Ecology
Mathematical models and experiments on the levels of selection in evolving metaorganisms
A4
Researchers
Researchers
A4.1: Mathematical models on the levels of selection in evolving metaorganisms
A4
Postdoctoral Researcher
Dr. Amanda de Azevedo-Lopes
A4
Associated Doctoral Candidate
Chandan Relekar
A4
Associated Postdoctoral Researcher
Dr. Michael Sieber
A4.3: Experimental analysis of the levels of selection in evolving metaorganisms
A4
Doctoral Candidate
Inga Hamerich
A4
Associated Postdoctoral Researcher
Dr. Julia Johnke
A4
Associated Doctoral Candidate
Janna Wülbern
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A4
PR
Z1
A4
Related Publications
Related Publications
2024
A4
Stochastic models allow improved inference of microbiome interactions from time series data
Zapién-Campos, R., Bansept, F., & Traulsen, A. (2024). PLoS biology, 22(11), e3002913. doi: https://doi.org/10.1371/journal.pbio.3002913
2024
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A4
Gut-associated functions are favored during microbiome assembly across a major part of C. elegans life
Zimmermann, J., Piecyk, A., Sieber, M., Petersen, C., Johnke, J., Moitinho-Silva, L., Künzel, S., Bluhm, L., Traulsen, A., Kaleta, C., & Schulenburg, H. (2024). Mbio, 15(5), e00012-24. doi: https://doi.org/10.1128/mbio.00012-24
2024
A1
A4
Z3
The C. elegans proteome response to two protective Pseudomonas symbionts
Pees, B.*, Peters, L., Treitz, C., Hamerich, I. K., Kissoyan, K. A., Tholey, A., & Dierking, K.* (2024). MBio, 15(4), e03463-23. doi: https://doi.org/10.1128/mbio.03463-23. *Shared corresponding authors
2023
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The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity
Ma Y, He J, Sieber M, von Frieling J, Bruchhaus I, Baines JF, Bickmeyer U, Roeder T (2023) The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity. Communications Biology 6: 289. https://doi.org/10.1038/s42003-023-04671-y.
2023
A4
Inferring interactions from microbiome data
Inferring interactions from microbiome data
2023
A1
A4
INF
Gut-associated functions are favored during microbiome assembly across C. elegans life
Zimmermann J*, Piecyk A*, Sieber M, Petersen C, Johnke J, Moitinho-Silva L, Künzel S, Bluhm L, Traulsen A, Kaleta C, Schulenburg H (2023) Gut-associated functions are favored during microbiome assembly across C. elegans life. bioRxiv doi:10.1101/2023.03.25.534195. *Shared first authorship.
2023
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Bacterial c-di-GMP has a key role in establishing host-microbe symbiosis
Obeng N, Czerwinski A, Schütz D, Michels J, Leipert J, Bansept F, García García MJ, Schultheiß T, Kemlein M, Fuß J, Tholey A, Traulsen A, Sondermann H, Schulenburg H (2023) Bacterial c-di-GMP has a key role in establishing host-microbe symbiosis. Nature Microbiology doi: 10.1038/s41564-023-01468-x.
2023
A4
Environmental selection overrides host selection in a horizontally acquired microbiota
Obeng N, Schulenburg H (2023) Environmental selection overrides host selection in a horizontally acquired microbiota. bioRxiv doi:10.1101/2023.03.22.533819
2022
A4
The effect of microbial selection on the occurrence-abundance patterns of microbiomes
Zapien-Campos, R., Sieber, M., and Traulsen, A. (2022) Journal of the Royal Society Interface. https://doi.org/10.1098/rsif.2021.0717
2022
A4
On the effect of inheritance of microbes in commensal microbiomes
Zapién-Campos, R., Bansept, F., Sieber, and Traulsen, A. BMC Ecol Evo 22, 75 (2022). https://doi.org/10.1186/s12862-022-02029-2
2021
A4
Featured
Modeling host-associating microbes under selection.
Bansept F, Obeng N, Schulenburg H, Traulsen A (2021) ISME J. 15(12):3648-3656. doi:10.1038/s41396-021-01039-0
2021
A4
Featured
Evolution of microbiota–host associations: the microbe’s perspective
Obeng N, Bansept F, Sieber M, Traulsen A, Schulenburg H (2021) Trends in Microbiol. 29(9):779-787. doi: 10.1016/j.tim.2021.02.005
2021
A4
Featured
On the evolutionary origins of host–microbe associations.
Sieber M, Traulsen A, Schulenburg H, Douglas AE (2021) PNAS. 10.1073/pnas.2016487118
2020
A4
Stochastic colonization of hosts with a finite lifespan can drive individual host microbes out of equilibrium
Zapien-Campos R, Sieber M, Traulsen A (2020) PLoS Comput Biol. 16(11): e1008392. doi: 10.1371/journal.pcbi.1008392
2020
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Microbiome-mediated plasticity directs host evolution along several distinct time scale
Kolodny O, Schulenburg H (2020) Phil. Trans. R. Soc. B. 375: 20190589. doi: 10.1098/rstb.2019.0589
2020
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Metaorganismusforschung trifft Schule: Wissenschaftskommunikation an der Universität zu Kiel.
Claussen C, Kapitza M, Knapp JM, Bernholt A, Schulenburg H, Kremer KH (2020). Biologie in unserer Zeit (BiuZ), 50(4), 270-277. doi: 10.1002/biuz.202010713
2020
A4
Community assembly of the native C. elegans microbiome is influenced by time, substrate and individual bacterial taxa
Johnke J, Dirksen P, Schulenburg H (2020) Environ. Microbiol. 22(4):1265–1279 doi: 10.1111/1462-2920.14932
2020
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INF
Featured
The functional repertoire contained within the native microbiota of the model nematode Caenorhabditis elegans
Zimmermann J*, Obeng N*, Yang W, Pees B, Petersen C, Waschina S, Kissoyan KAB, Aidley J, Hoeppner MP, Bunk B, Spröer C, Leippe M, Dierking K, Kaleta C*, Schulenburg H* (2019) ISME J. 14: 26–38. * Shared first or senior authorship doi: 10.1038/s41396-019-0504-y
2020
A4
B1
Bdellovibrio and like organisms are predictors of microbiome diversity across diverse host groups.
Johnke J, Fraune S, Bosch TCG, Hentschel U, Schulenburg H (2020) Microbial Ecology. 79: 252–257. doi: 10.1007/s00248-019-01395-7
2019
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Featured
Advancing our functional understanding of host–microbiota interactions: a need for new types of studies
He J, Lange J, Marinos G, Bathia J, Harris D, Soluch R, Vaibhvi V, Deines P, Hassani MA, Wagner K-S, Zapien‐Campos R, Jaspers C, Sommer F (2019) BioEssays, 1900211 (1-5). doi: 10.1002/bies.201900211
2019
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Featured
A phage protein aids bacterial symbionts in eukaryote immune evasion
Jahn MT, Arkhipova K, Markert SM, Stigloher C, Lachnit T, Pita L, Kupczok A, Ribes M, Stengel ST, Rosenstiel P, Dutilh BE, Hentschel U (2019) Cell Host & Microbe, doi: 10.1016/j.chom.2019.08.019
2019
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INF
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The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life
Yang W#, Petersen C#, Pees B#, Zimmermann J, Waschina S, Dirksen P, Rosenstiel P, Tholey A, Leippe M, Dierking K, Kaleta C*, Schulenburg H*. Front Microbiol. 10:1793. # Equal contribution as first authors, * Equal contribution as senior authors doi: 10.3389/fmicb.2019.01793.
2019
A4
B1
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Featured
Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
Mortzfeld BM*, Taubenheim J*, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019) Nature Communications 10, 3257. doi: 10.1038/s41467-019-11136-6
2019
A4
C1
The microbiome mediates environmental effects on ageing
Finlay B, Pettersson S, Melby M, Bosch TCG (2019) BioEssays, 1800257, 1-7; doi: 10.1002/bies.201800257
2019
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A4
B1
B2
Featured
Neutrality in the metaorganism
Sieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, Traulsen A (2019) PLoS Biol., DOI: 10.1371/journal.pbio.3000298
2019
A4
C1
Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying diversity of host-microbe interactions
Bosch TCG, Guillemin K, McFall-Ngai M (2019) BioEssays, 1800256 (1-8). doi: 10.1002/bies.201800256
2019
A4
Exposure of the host-associated microbiome to nutrient-rich conditions may lead to dysbiosis and disease development – an evolutionary perspective.
Lachnit T, Bosch TCG, Deines P (2019) mBio (Opinion article); 10:3, e00355-19, 1-8, doi: 10.1128/mBio.00355-19
2019
A4
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Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches
Jaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Zoology. doi: 10.1016/j.zool.2019.02.007
2018
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Hydra as Model to Determine the Role of FOXO in Longevity
Bosch TCG (2018); Methods Mol Biol. 1890:231-238. doi: 10.1007/978-1-4939-8900-3_19
2018
A4
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Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.
Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC (2018); Elife 7. pii: e35122. doi: 10.7554/eLife.35122
2018
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Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy
Von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Thomas C. G. Bosch TCG, Roeder T, P Rosenstiel P, Sommer F (2018); Front. Microbiol. doi: 10.3389/fmicb.2018.02020
2018
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Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont.
Klimovich AV, Bosch TCG (2018); Bioessays 40(9):e1800060. doi: 10.1002/bies.201800060
2018
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Non-senescent Hydra tolerates severe disturbances in the nuclear lamina.
Klimovich A, Rehm A, Wittlieb J, Herbst EM, Benavente R, Bosch TCG (2018); Aging (Albany NY) 10(5):951-972. doi: 10.18632/aging.101440
2018
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Stem cell transcription factor FoxO controls microbiome resilience in Hydra.
Mortzfeld B M, Taubenheim J,Fraune S, Klimovich A V, Bosch T C G (2018); Front Microbiol., doi: 10.3389/fmicb.2018.00629
2018
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Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?
Bang C, Dagan T, Deines P, Dubilier N, Duschl W J, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Galan P L, Pogoreutz C, Rädecker N, Saad M M, Schmitz R A, Schulenburg H, Voolstra C R, Weiland-Bräuer N, Ziegler M, Bosch T C G (2018); Zoology, doi: 10.1016/j.zool.2018.02.004
2018
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How the microbiome challenges our concept of self.
Rees T, Bosch T G C, Douglas A E (2018); PloS Biol., 16(2):e2005358. doi:10.1371/journal.pbio.2005358
2017
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Temperate phages as self-replicating weapons in bacterial competition.
Li XY, Lachnit T, Fraune S, Bosch T C G, Traulsen A, Sieber M (2017); J R Soc Interface, 14(137). doi: 10.1098/rsif.2017.0563
2017
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Spontaneous body contractions are modulated by the microbiome of Hydra.
Murillo-Rincon A P, Klimovich A, Pemöller E, Taubenheim J, Mortzfeld B, Augustin R, Bosch T C G (2017); Scientific Reports, 7(15937). doi:10.1038/s41598-017-16191-x
2017
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Featured
A secreted antibacterial neuropeptide shapes the microbiome of Hydra.
Augustin R, Schröder K, Murillo Rincón A P, Fraune S, Anton-Erxleben F, Herbst E M, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar T M, Bosch T C G (2017); Nat Commun., 8(1):698. doi: 10.1038/s41467-017-00625-1
2017
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The Natural Biotic Environment of Caenorhabditis elegans.
Schulenburg H, Félix M A (2017); Genetics., 206(1):55-86. doi: 10.1534/genetics.116.195511
2017
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Caenorhabditis elegans as a model for microbiome research.
Zhang F, Berg M, Dierking K, Félix M A, Shapira M, Samuel B, Schulenburg H (2017); Front. Microbiol., 8:485. doi: 10.3389/fmicb.2017.00485
2016
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Emerging Sponge Models of Animal-Microbe Symbioses.
Pita L, Fraune S, Hentschel U (2016); Front Microbiol., 7:2102. doi: 10.3389/fmicb.2016.02102
2016
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The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra.
Schröder K, Bosch T C (2016); MBio., 7(6):e01184-16. doi: 10.1128/mBio.01184-16
2016
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Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model.
Deines P, Bosch T C G (2016); Front. Microbiol., 7:1610. doi: 10.3389/fmicb.2016.01610
2016
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Using Nematostella vectensis to Study the Interactions between Genome, Epigenome, and Bacteria in a Changing Environment.
Fraune S, Forêt S, Reitzel A M (2016); Front. Mar. Sci., 3:148. doi: 10.3389/fmars.2016.00148
2016
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The native microbiome of the nematode Caenorhabditis elegans: Gateway to a new host-microbiome model.
Dirksen P, Marsh SA, Braker I, Heitland N, Wagner S, Nakad R, Mader S, Petersen C, Kowallik V, Rosenstiel P C, Felix M A, Schulenburg H (2016); BMC Biology, 14:38. doi:10.1186/s12915-016-0258-1
2016
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Antimicrobial effectors in the nematode C. elegans – an outgroup to the Arthropoda.
Dierking K, Yang W, Schulenburg H (2016); Phil Trans R Soc Lond B., 371. doi: