Project B1 (PIs Hentschel, Fraune, Roth) uses cross-host comparisons to study the molecular and cellular mechanisms that underlie the host differentiation between – and response to – native and nonnative microbes in marine metazoans. The project will also evaluate the routes of transmission and their influence on bacterial colonization in the next generation in the model systems sponge, Nematostella, and teleost fish. The project is joined by the new PI Roth, who enriches it with her unique focus on microbiota transmission during male pregnancy in pipefish, enabling a comparison of immune responses between vertebrates and invertebrates.
B1
Recognition and Communication
Host-microbe cross talk in three marine taxa (Porifera, Cnidaria and teleost fish)
B1
Researchers
Researchers
B1.1: Mechanistic and cellular underpinnings of sponge-microbe cross talk
B1
B1
Associated Postdoctoral Researcher
Dr. Tyler Carrier
B1
C4
B1.2: Mechanisms and consequences of selective phagocytosis by nematosomes
B1
Associated Postdoctoral Researcher
Dr. Jay Bathia
B1
Associated Postdoctoral Researcher
Dr. Hanna Domin
B1
B1
B1.3: The interplay of microbial transmission and host immune defense in a pipefish with male pregnancy
B1
Associated Doctoral Candidate
Kim Sara Wagner
B1
B1
Principal Investigator, Steering Committee
Prof. Dr. Olivia Roth
B1
Related Publications
Related Publications
2024
B1
Shaping tiny worlds: Paternal microbiota manipulation influences offspring microbial colonization and development in a sex role-reversed pipefish
Wagner, K. S., Salasc, F., Marten, S. M., & Roth, O. (2024). bioRxiv, 2024-10. doi: https://doi.org/10.1101/2024.10.09.617486
2024
B1
Transcriptomic responses of Mediterranean sponges upon encounter with symbiont microbial consortia
Marulanda-Gomez, A. M., Ribes, M., Franzenburg, S., Hentschel, U., & Pita, L. (2024). BMC genomics, 25(1), 674. doi: https://doi.org/10.1186/s12864-024-10548-z
2023
B1
Maternal provisioning of an obligate symbiont
Carrier TJ, Schmittmann L, Jung S, Pita L, Hentschel U. Maternal provisioning of an obligate symbiont in a sponge. Ecology and Evolution. 2023; 13: e10012 DOI: 10.1002/ece3.10012
2023
B1
A novel in-vivo phagocytosis assay to gain cellular insights on sponge-microbe interactions
2023
B1
Genotype-environment interactions determine microbiota plasticity in Nematostella vectensis
Baldassarre L, Reitzel A, Fraune S, (2023), PLoS Biol. 21(1): e3001726. https://doi.org/10.1371/journal.pbio.3001726
2023
A1
B1
INF
Z2
Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis
Domin H, Zimmermann J, Taubenheim J, Fuentes Reyes G, Saueressig L, Prasse D, Höppner M, Schmitz RA, Hentschel U, Kaleta C, Fraune S (2023) Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis. Microbiome doi:10.1186/s40168-023-01701-z
2022
B1
C4
Sponge-symbiont stability in spite of antibiotic-induced microbiome disturbance
Schmittmann L, Rahn T, Busch K, Fraune S, Pita L, Hentschel U. (2022) Environ. Microbiol. 24: 6392-6410, https://doi.org/10.1111/1462-2920.16249
2022
B1
Harnessing the power of model organisms to unravel coral holobiont complexity
Puntin G., Sweet M, Fraune S., Medina M., Weiss V, Ziegler M (2022) Microbiol. Mol. Biol. Reviews, 21;86(4):e0005322, https://doi.org/10.1128/mmbr.00053-22
2022
B1
Stability of a dominant sponge-symbiont in spite of antibiotic-induced microbiome disturbance
Schmittmann L, Rahn T, Busch K, Fraune S, Pita L, Hentschel U. Stability of a dominant sponge-symbiont in spite of antibiotic-induced microbiome disturbance (2022) Environ. Microbiol. 24: 6392-6410, https://doi.org/10.1111/1462-2920.16249
2022
B1
Pigmentation biosynthesis influences the microbiome in sea urchins
Wessel Gary M. Kiyomoto Masato, Reitzel Adam M and Carrier Tyler J. (2022) in R. Soc. B. 289: 20221088 20221088 http://doi.org/10.1098/rspb.2022.1088
2022
B1.1
B1
Featured
Biodiversity, environmental drivers, and sustainability of the global deep-sea sponge microbiome
Kathrin Busch, Beate M. Slaby, Wolfgang Bach, Antje Boetius, Ina Clefsen, Ana Colaço, Marie Creemers, Javier Cristobo, Luisa Federwisch, Andre Franke, Asimenia Gavriilidou, Andrea Hethke, Ellen Kenchington, Furu Mienis, Sadie Mills, Ana Riesgo, Pilar Ríos, Emyr Martyn Roberts, Detmer Sipkema, Lucía Pita, Peter J. Schupp, Joana Xavier, Hans Tore Rapp & Ute Hentschel (2022) Nature Communications. 13: 5160. doi: 1038/s41467-022-32684-4
2022
B1.2
B1
Featured
Microbiota mediated plasticity promotes thermal adaptation in the sea anemone Nematostella vectensis
Laura Baldassarre, Hua Ying, Adam M. Reitzel, Sören Franzenburg, Sebastian Fraune (2022): Nature Communications, 13, Article number: 3804 doi: 10.1038/s41467-022-31350-z
2022
B1
On the spread of microbes that manipulate reproduction in marine invertebrates.
Kustra MC, Carrier TJ (2022) The American Naturalist. 200(20):1-19. doi: 1086/720282
2022
B1
C1
C4
Symbiotic Algae of Hydra viridissima Play a Key Role in Maintaining Homeostatic Bacterial Colonization.
Bathia J, Schröder K, Fraune S, Lachnit T, Rosenstiel P, Bosch TCG (2022) Front. Microbiol. 13:869666. doi: 10.3389/fmicb.2022.869666
2022
B1
C1
Symbiont transmission in marine sponges: reproduction, development, and metamorphosis
Carrier TJ, Maldonado M, Schmittmann L, Pita L, Bosch TCG, Hentschel U (2022) BMC Biology 20(1):100 doi: 10.1186/s12915-022-01291-6
2022
B1
Z3
Population differences and host species predict variation in the diversity of host-associated microbes in Hydra
Taubenheim J, Miklós M, Tökölyi J, Fraune S (2022). Front. Microbiol. 13:799333. doi: 10.3389/fmicb.2022.799333
2022
B1
C1
Featured
The role of DNA methylation in genome defense in Cnidaria and other invertebrates
Ying H, Hayward DC, Klimovich A, Bosch TCG, Baldassarre L, Neeman T, Forêt S, Huttley G, Reitzel AM, Fraune S, Ball EE, Miller DJ (2022) Molecular Biology and Evolution, msac018, doi: 10.1093/molbev/msac018
2021
B1
Contribution of maternal and paternal transmission to bacterial colonization in Nematostella vectensis.
Baldassarre L, Levy S, Bar-Shalom R, Steindler L, Lotan T, Fraune S (2021) Front Microbiol. 12: 726795. doi: 3389/fmicb.2021.726795
2021
B1
C4
Featured
Harnessing the power of host–microbe symbioses to address grand challenges.
Hentschel U (2021) Nat Rev Microbiol. 19, 615–616. doi: 10.1038/s41579-021-00619-3
2021
B1
Individuality in the Immune Repertoire and Induced Response of the Sponge Halichondria panacea
Schmittmann L, Franzenburg S, Pita L (2021) Front Immunol. 12:689051. doi: 3389/fimmu.2021.689051.
2021
B1
Hydra and Curvibacter – an intimate crosstalk at the epithelial interface. In: Cellular Dialogues in the Holobiont.
Minten T, Fraune S (2021) ed. by Bosch, Thomas C. G. and Hadfield, Michael G.. CRC Press, Boca Raton, Fla., USA, pp. 79-89 ISBN 9780429277375 doi: 1201/9780429277375-4.
2021
B1
Decoding cellular dialogues between sponges, bacteria, and phages. In: Cellular Dialogues in the Holobiont.
Schmittmann L, Jahn MT, Pita L, Hentschel U (2021) ed. by Bosch, Thomas C. G. and Hadfield, Michael G.. CRC Press, Boca Raton, Fla., USA, pp. 49-63. ISBN 9780429277375 doi: 1201/9780429277375-4.
2021
B1
C4
Featured
Lifestyle of sponge symbiont phages by host prediction and correlative microscopy
Jahn MT, Lachnit T, Markert SM, Stigloher C, Pita L, Ribes M, Dutilh BE, Hentschel U (2021) ISME J. doi: 10.1038/s41396-021-00900-6
2020
B1
C1
Featured
Bacteria- and temperature-regulated peptides modulate beta-catenin signalling in Hydra
Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J, Bosch TCG, Fraune S (2020) PNAS. 117(35):21459-21468. doi: 10.1073/pnas.2010945117
2020
B1
Featured
Heterotrophy in the earliest gut: a single-cell view of heterotrophic carbon and nitrogen assimilation in sponge-microbe symbioses
Rix L, Ribes M, Coma R, Jahn M, van Oevelen D, de Goeij J, Escrig S, Meibom A, Hentschel U (2020) ISME J. 14, 2554–2567. doi: 10.1038/s41396-020-0706-3
2020
A1
B1
Receptors mediating host-microbiota communication in the metaorganism: the invertebrate perspective.
Dierking K, Pita L (2020) Front. Immunol. 11:1251. doi: 10.3389/fimmu.2020.01251
2020
A4
B1
Bdellovibrio and like organisms are predictors of microbiome diversity across diverse host groups.
Johnke J, Fraune S, Bosch TCG, Hentschel U, Schulenburg H (2020) Microbial Ecology. 79: 252–257. doi: 10.1007/s00248-019-01395-7
2019
A4
B1
C2
Featured
A phage protein aids bacterial symbionts in eukaryote immune evasion
Jahn MT, Arkhipova K, Markert SM, Stigloher C, Lachnit T, Pita L, Kupczok A, Ribes M, Stengel ST, Rosenstiel P, Dutilh BE, Hentschel U (2019) Cell Host & Microbe, doi: 10.1016/j.chom.2019.08.019
2019
A1
A2
A3
B1
B2
C1
C2
INF
Z3
Featured
Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms
Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1
2019
A4
B1
C1
C2
Featured
Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
Mortzfeld BM*, Taubenheim J*, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019) Nature Communications 10, 3257. doi: 10.1038/s41467-019-11136-6
2019
A2
A4
B1
B2
Featured
Neutrality in the metaorganism
Sieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, Traulsen A (2019) PLoS Biol., DOI: 10.1371/journal.pbio.3000298
2019
A4
B1
B2
Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches
Jaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Zoology. doi: 10.1016/j.zool.2019.02.007
2019
B1
Featured
Fueled by methane: deep-sea sponges from asphalt seeps gain their nutrition from methane-oxidizing symbionts
Rubin-Blum M, Antony CP, Sayavedra L, Martínez-Pérez C, Birgel D, Peckmann J, Wu Y, Cardenas P, MacDonald I, Marcon Y, Sahling H, Hentschel U, Dubilier N (2019) The ISME Journal , v 13, p 1209–1225. doi: 10.1038/s41396-019-0346-7
2018
B1
INF
Z2
Differential expression of immune receptors in two marine sponges upon exposure to microbial-associated molecular patterns.
Pita L, Hoeppner MP, Ribes M, Hentschel U (2018); Sci Rep. 8(1):16081.doi: 10.1038/s41598-018-34330-w
2018
A4
B1
C1
Z1
Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.
Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC (2018); Elife 7. pii: e35122. doi: 10.7554/eLife.35122
2018
B1
Predicted bacterial interactions affect in vivo microbial colonization dynamics in Nematostella
Domin H, Zurita-Gutiérrez Y, Scotti M, Buttlar J, Hentschel Humeida U and Fraune S (2018) Frontiers in Microbiology 9, 728, https://doi.org/10.3389/fmicb.2018.00728
2018
A4
B1
C1
Z1
Stem cell transcription factor FoxO controls microbiome resilience in Hydra.
Mortzfeld B M, Taubenheim J,Fraune S, Klimovich A V, Bosch T C G (2018); Front Microbiol., doi: 10.3389/fmicb.2018.00629
2018
A2
B1
INF
Z2
The sponge holobiont in a changing ocean: from microbes to ecosystems.
Pita L, Rix L, Slaby B M, Franke A, Hentschel U (2018); Microbiome, 6(46). doi: 10.1186/s40168-018-0428-1
2018
A1
A2
A3
A4
B1
B2
C1
Z1
Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?
Bang C, Dagan T, Deines P, Dubilier N, Duschl W J, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Galan P L, Pogoreutz C, Rädecker N, Saad M M, Schmitz R A, Schulenburg H, Voolstra C R, Weiland-Bräuer N, Ziegler M, Bosch T C G (2018); Zoology, doi: 10.1016/j.zool.2018.02.004
2017
A4
B1
C1
Z1
Temperate phages as self-replicating weapons in bacterial competition.
Li XY, Lachnit T, Fraune S, Bosch T C G, Traulsen A, Sieber M (2017); J R Soc Interface, 14(137). doi: 10.1098/rsif.2017.0563
2017
A4
B1
C1
Z1
Featured
A secreted antibacterial neuropeptide shapes the microbiome of Hydra.
Augustin R, Schröder K, Murillo Rincón A P, Fraune S, Anton-Erxleben F, Herbst E M, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar T M, Bosch T C G (2017); Nat Commun., 8(1):698. doi: 10.1038/s41467-017-00625-1
2016
A4
B1
Z2
Emerging Sponge Models of Animal-Microbe Symbioses.
Pita L, Fraune S, Hentschel U (2016); Front Microbiol., 7:2102. doi: 10.3389/fmicb.2016.02102
2016
B1
Z2
Shedding light on cell compartmentation in the candidate phylum Poribacteria by high resolution visualisation and transcriptional profiling.
Jahn M T, Markert S M, Ryu T, Ravasi T, Stigloher C, U Hentschel, Moitinho-Silva L (2016); Scientific Reports, 6:35860. doi: 10.1038/srep35860
2016
A4
B1
Using Nematostella vectensis to Study the Interactions between Genome, Epigenome, and Bacteria in a Changing Environment.
Fraune S, Forêt S, Reitzel A M (2016); Front. Mar. Sci., 3:148. doi: 10.3389/fmars.2016.00148