Project C1 (PIs Bosch, Gruber-Vodicka) aims to explore the impact of microbes on senescence and life history switches in two stem bilaterians: Hydra and placozoans using a comparative approach. This includes focusing on the role of the microbiome in maintaining non-senescence in H. oligactis polyps during the switch from asexual to sexual reproduction, as well as investigating the role of intracellular bacteria in life history switches in placozoans and Hydra. The project is joined by the new PI Gruber-Vodicka, who complements the project aims with a focus on host-microbe interactions in placozoans.
C1
Function and Life History
Impact of symbiosis on life history decisions at the base of the metazoan evolution: lessons from placozoans and Hydra
C1
Researchers
Researchers
C1.1: What role does the microbiome play in maintaining non-senescence in Hydra
C1
C1
Associated Doctoral Candidate
Christopher Noack
C1
Associated Postdoctoral Researcher
Dr. Alexander Klimovich
C1
PR
Principal Investigator, Steering Committee
Prof. Dr. Dr. h.c. Thomas C.G. Bosch
C1.3: What is the role of intracellular Midichloriaceae in placozoans and Hydra, with a focus on environmentally induced life history switches?
C1
C1
Associated Doctoral Candidate
Igor Duarte
C1
Associated Postdoctoral Researcher
Dr. Jinru He
C1
Principal Investigator
Prof. Dr. Harald Gruber-Vodicka
C1
Related Publications
Related Publications
2024
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C1
Wie arbeitet Wissenschaft heute? Vernetzte Zugänge für Universität und Schule
Parchmann, I., Bosch, T. B., Claussen, C., Duscher, T., Enzingmüller, C., Knüver, J., & Schulenburg, H. (2024). MNU-Journal/Verband zur Förderung des MINT-Unterrichts, 2024(1), 29-36.
2024
C1
Satiety controls behavior in Hydra through an interplay of pre-enteric and central nervous system-like neuron populations
Giez, C., Noack, C., Sakib, E., Hofacker, L. M., Repnik, U., Bramkamp, M., & Bosch, T. C. (2024). Cell Reports, 43(6). doi: https://doi.org/10.1016/j.celrep.2024.114210
2024
C1
Featured
The potential importance of the built-environment microbiome and its impact on human health
Bosch, T. C., Wigley, M., Colomina, B., Bohannan, B., Meggers, F., Amato, K. R., Azad, M. B., Blaser, M. J., Brown, K., Dominguez-Bello, M. G., Ehrlich, S. D., Elinav, E., Finlay, B., Geddie, K., Geva-Zatorsky, N., Giles-Vernick, T., Gros, P., Guillemin, K., Haraoui, L. P., Johnson, E., Keck, F., Lorimer, J., McFall-Ngai, M. J., Nichter, M., Petterson, S., Poinar, H., Rees, T., Tropini, C., Undurraga, E. A., Zhao, L., & Melby, M. K. (2024). Proceedings of the National Academy of Sciences, 121(20), e2313971121. doi: https://doi.org/10.1073/pnas.2313971121
2023
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The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity
Ma Y, He J, Sieber M, von Frieling J, Bruchhaus I, Baines JF, Bickmeyer U, Roeder T (2023) The microbiome of the marine flatworm Macrostomum lignano provides fitness advantages and exhibits circadian rhythmicity. Communications Biology 6: 289. https://doi.org/10.1038/s42003-023-04671-y.
2023
C1
Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host-microbe associations
Nawroth JC, Giez C, Klimovich A, Kanso EA, Bosch TCG (2023) Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host-microbe associations. eLife doi: 10.7554/eLife.83637.
2023
C1
Microbes as part of ancestral neuronal circuits: Bacterial produced signals affect neurons controlling eating behavior in Hydra.
Giez C, Pinkle D, Giencke Y, Wittlieb J, Herbst E, Spratte T, Lachnit T, Klimovich A, Selhuber-Unkel C, Bosch TCG (2023) Microbes as part of ancestral neuronal circuits: Bacterial produced signals affect neurons controlling eating behavior in Hydra. bioRxiv doi: 10.1101/2023.04.28.538719
2022
C1
Symbiosis: the other cells in development
Tyler J. Carrier, Thomas C. G. Bosch (2022) Development. 49 (13): dev200797.
doi: 10.1242/dev.200797
2022
C1
Beyond Lynn Margulis’ green hydra
Bosch, T. C. (2022). Symbiosis, 87(1), 11-17.
2022
B1
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C4
Symbiotic Algae of Hydra viridissima Play a Key Role in Maintaining Homeostatic Bacterial Colonization.
Bathia J, Schröder K, Fraune S, Lachnit T, Rosenstiel P, Bosch TCG (2022) Front. Microbiol. 13:869666. doi: 10.3389/fmicb.2022.869666
2022
B1
C1
Symbiont transmission in marine sponges: reproduction, development, and metamorphosis
Carrier TJ, Maldonado M, Schmittmann L, Pita L, Bosch TCG, Hentschel U (2022) BMC Biology 20(1):100 doi: 10.1186/s12915-022-01291-6
2022
C1
Wenn das Mikrobiom den Nerven trifft: Hydra hilft den Blick auf die Interaktion von Mikroben und Nervenzellen zu vertiefen
Bosch T & Giez C (2022). Wenn das Mikrobiom den Nerven trifft: Hydra hilft den Blick auf die Interaktion von Mikroben und Nervenzellen zu vertiefen. Biologie in Unserer Zeit, 52(4), 352–362. https://doi.org/10.11576/biuz-5866
2022
C1
Hydra´s lasting partnership with microbes: key for escaping senescence?
He J, Bosch TCG (2022) Microorganisms 10(4):774. doi: 10.3390/microorganisms10040774
2022
C1
C4
Hydra and the hair follicle – An unconventional comparative biology approach to exploring the human holobiont.
Lousada MB, Lachnit T, Edelkamp J, Paus R, Bosch TCG (2022 ) Bioessays. 44(5):e2100233. doi: 10.1002/bies.202100233.
2022
B1
C1
Featured
The role of DNA methylation in genome defense in Cnidaria and other invertebrates
Ying H, Hayward DC, Klimovich A, Bosch TCG, Baldassarre L, Neeman T, Forêt S, Huttley G, Reitzel AM, Fraune S, Ball EE, Miller DJ (2022) Molecular Biology and Evolution, msac018, doi: 10.1093/molbev/msac018
2021
C1
Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome
Bosch TCG, Zasloff M (2021) mBio. 12(5):e01847-21. doi: 10.1128/mBio.01847-21
2021
C1
Featured
Taking a microscale look at symbiotic interactions—and why it matters
Bosch TCG (2021) PNAS.
2021
C1
Featured
Beating in on a stable partnership.
Giez C, Bosch TCG (2021) Nat Rev Microbiol. doi: 10.1038/s41579-021-00575-y
2021
C1
Neurons interact with the microbiome: an evolutionary-informed perspective
Giez C, Klimovich A, Bosch TCG (2021) Neuroforum 27(2): 89–98. doi 10.1515/nf-2021-0003
2021
C1
Animal development in the microbial world: Re-thinking the conceptual framework.
Bosch TCG and McFall-Ngai M (2021) Current Topics in Developmental Biology. 141:399-427. ISSN 0070-2153. doi: 10.1016/bs.ctdb.2020.11.007
2021
C1
Animal development in the microbial world: The power of experimental model systems.
McFall-Ngai M and Bosch TCG (2021) Current Topics in Developmental Biology. 141: 371-397. ISSN 0070-2153. doi: 10.1016/bs.ctdb.2020.10.002
2021
C1
Featured
The hygiene hypothesis, the COVID pandemic, and consequences for the humanmicrobiome
Finlay BB, Amato KR, Azad M, Blaser MJ, Bosch TCG, Chu H, Dominguez-Bello MG, Ehrlich SD, Elinav E, Geva-Zatorsky N, Gros P, Guillemin K, Keck F, Korem T, McFall-Ngai MJ, Melby MK, Nichter M, Pettersson S, Poinar H, Rees T, Tropini C, Zhao L, Giles-Vernick T (2021) PNAS. doi: 10.1073/pnas.2010217118
2020
B1
C1
Featured
Bacteria- and temperature-regulated peptides modulate beta-catenin signalling in Hydra
Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J, Bosch TCG, Fraune S (2020) PNAS. 117(35):21459-21468. doi: 10.1073/pnas.2010945117
2020
C1
Exploring the niche concept in a simple metaorganism
Deines P, Hammerschmidt K, TCG Bosch (2020) Frontiers in Microbiology, 11:1942, 1-11. doi: 10.3389/fmicb.2020.01942
2020
C1
Microbial species coexistence depends on the host environment
Deines P, Hammerschmidt K, Bosch TCG (2020) mBio 11:e00807-20. doi: 10.1128/mBio.00807-20.
2020
C1
Featured
Prototypical pacemaker neurons interact with the resident microbiota
2020
C1
INF
Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra.
Rathje K, Mortzfeld B, Hoeppner MP, Taubenheim J, Bosch TCG, Klimovich A (2020) PLoS Pathog. 16(3):e1008375. doi: 10.1371/journal.ppat.1008375
2020
C1
Featured
Are noncommunicable diseases communicable?
Finlay BB, Blaser MJ, Bosch TCG, Dominguez-Bello MG, Elinav E, McFall-Ngai M, Melby MK, Muehlmann SR, Sansonetti PJ (2020) Science. 367(6475): 250-251. doi: 10.1126/science.aaz3834
2019
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INF
Featured
Advancing our functional understanding of host–microbiota interactions: a need for new types of studies
He J, Lange J, Marinos G, Bathia J, Harris D, Soluch R, Vaibhvi V, Deines P, Hassani MA, Wagner K-S, Zapien‐Campos R, Jaspers C, Sommer F (2019) BioEssays, 1900211 (1-5). doi: 10.1002/bies.201900211
2019
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INF
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Featured
Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms
Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1
2019
A4
B1
C1
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Featured
Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
Mortzfeld BM*, Taubenheim J*, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019) Nature Communications 10, 3257. doi: 10.1038/s41467-019-11136-6
2019
C1
Featured
Transgenesis in Hydra to characterize gene function and visualize cell behaviour.
Klimovich A, Wittlieb J, Bosch TCG (2019) Nat. Protoc., 1-24. doi: 10.1038/s41596-019-0173-3
2019
A4
C1
The microbiome mediates environmental effects on ageing
Finlay B, Pettersson S, Melby M, Bosch TCG (2019) BioEssays, 1800257, 1-7; doi: 10.1002/bies.201800257
2019
A4
C1
Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying diversity of host-microbe interactions
Bosch TCG, Guillemin K, McFall-Ngai M (2019) BioEssays, 1800256 (1-8). doi: 10.1002/bies.201800256
2018
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INF
Z2
Functions of the Microbiota for the Physiology of Animal Metaorganisms
Esser D, · Lange J, · Marinos G, · Sieber M, Best L, Prasse D, Bathia J, Rühlemann MC, Boersch K, Jaspers C, Sommer F (2018) J Innate Immun DOI: 10.1159/000495115
2018
A4
C1
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Hydra as Model to Determine the Role of FOXO in Longevity
Bosch TCG (2018); Methods Mol Biol. 1890:231-238. doi: 10.1007/978-1-4939-8900-3_19
2018
A4
B1
C1
Z1
Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.
Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC (2018); Elife 7. pii: e35122. doi: 10.7554/eLife.35122
2018
A4
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Z3
Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy
Von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Thomas C. G. Bosch TCG, Roeder T, P Rosenstiel P, Sommer F (2018); Front. Microbiol. doi: 10.3389/fmicb.2018.02020
2018
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Non-senescent Hydra tolerates severe disturbances in the nuclear lamina.
Klimovich A, Rehm A, Wittlieb J, Herbst EM, Benavente R, Bosch TCG (2018); Aging (Albany NY) 10(5):951-972. doi: 10.18632/aging.101440
2018
A4
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Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont.
Klimovich AV, Bosch TCG (2018); Bioessays 40(9):e1800060. doi: 10.1002/bies.201800060
2018
A3
C1
Carrying capacity and colonization dynamics of Curvibacter in the Hydra host habitat
Wein T, Dagan T, Fraune S, Bosch TCG, Reusch TBH and Hülter NF (2018) Front. Microbiol., https://doi.org/10.3389/fmicb.2018.00443
2018
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Stem cell transcription factor FoxO controls microbiome resilience in Hydra.
Mortzfeld B M, Taubenheim J,Fraune S, Klimovich A V, Bosch T C G (2018); Front Microbiol., doi: 10.3389/fmicb.2018.00629
2018
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Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?
Bang C, Dagan T, Deines P, Dubilier N, Duschl W J, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Galan P L, Pogoreutz C, Rädecker N, Saad M M, Schmitz R A, Schulenburg H, Voolstra C R, Weiland-Bräuer N, Ziegler M, Bosch T C G (2018); Zoology, doi: 10.1016/j.zool.2018.02.004
2018
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How the microbiome challenges our concept of self.
Rees T, Bosch T G C, Douglas A E (2018); PloS Biol., 16(2):e2005358. doi:10.1371/journal.pbio.2005358
2017
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Temperate phages as self-replicating weapons in bacterial competition.
Li XY, Lachnit T, Fraune S, Bosch T C G, Traulsen A, Sieber M (2017); J R Soc Interface, 14(137). doi: 10.1098/rsif.2017.0563
2017
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Spontaneous body contractions are modulated by the microbiome of Hydra.
Murillo-Rincon A P, Klimovich A, Pemöller E, Taubenheim J, Mortzfeld B, Augustin R, Bosch T C G (2017); Scientific Reports, 7(15937). doi:10.1038/s41598-017-16191-x
2017
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Featured
A secreted antibacterial neuropeptide shapes the microbiome of Hydra.
Augustin R, Schröder K, Murillo Rincón A P, Fraune S, Anton-Erxleben F, Herbst E M, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar T M, Bosch T C G (2017); Nat Commun., 8(1):698. doi: 10.1038/s41467-017-00625-1
2016
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The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra.
Schröder K, Bosch T C (2016); MBio., 7(6):e01184-16. doi: 10.1128/mBio.01184-16
2016
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Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model.
Deines P, Bosch T C G (2016); Front. Microbiol., 7:1610. doi: 10.3389/fmicb.2016.01610