Core project Z2 (PIs Schmitz-Streit, Bramkamp) aims to provide support in the targeted isolation and taxonomic classification of host-associated bacteria, with a focus on anaerobic bacteria and archaea in the gut microbiome. It will also support the establishment of protocols for random mutagenesis. The project is joined by the new PI Bramkamp, who provides a platform for microscopic analysis of host-microbe interactions, in order to obtain a precise spatial understanding of host-microbiome interactions and their functions.