Principal Investigator

Prof. Dr. Sebastian Fraune

Institution

Heinrich Heine University Düsseldorf
Institute of Zoology and Organismic Interactions
Vita

Education/Training

2005 – 2009
Dissertation at the Christian-Albrechts University of Kiel, Zoological Institute, (supervised by Prof. Dr. Dr. h.c. Bosch), Title: Towards understanding a holobiont: Host-microbe interaction in Hydra; “summa cum laude”

1999 – 2005
Diploma in Biology (Microbiology, Limnology, Toxicology), Christian-Albrechts University of Kiel, Germany

Research Experience/Academic Appointments

Since 2019
Professor for Zoology and Organismic Interactions (W2), Heinrich-Heine University Düsseldorf

2013 – 2018
Independent junior research group leader at the Christian-Albrechts University of Kiel, Zoological Institute

2009 – 2013
Postdoctoral Fellow, Zoological Institute, Christian-Albrechts-University of Kiel, Germany, group of Prof. Dr. Dr. h.c. Thomas Bosch

Important Scientific Prizes/Functions

Since 2013
Editorial service for scientific journal: Frontiers in Microbial Symbiosis – Associate Editor

Since 2012
Referee service for scientific journals: Nature Communications, PNAS, ISMEJ, eLife, Environmental Microbiology, BMC Genomics, PLoS ONE, Marine Biology, Bioessays, Frontiers in Microbial Symbiosis

2011
Awards: Poster Prize, Gordon Research Conference Antimicrobial Peptides in Innate Immunity – New Insights on an Ancient System

2008
Travel grant to participate at the 2nd ASM Conference on Beneficial Microbes, San Diego (USA)

Contact

+49 211 81 14991
+49 211 81 11971
fraune@hhu.de
https://www.organismicinteractions.hhu.de/ https://gepris.dfg.de/gepris/person/197934751

Associated Research Groups

Prof. Dr. Sebastian Fraune
Publications

Publications

Filter by

Year All
2023
A1
B1
INF
Z2

Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis

Domin H, Zimmermann J, Taubenheim J, Fuentes Reyes G, Saueressig L, Prasse D, Höppner M, Schmitz RA, Hentschel U, Kaleta C, Fraune S (2023) Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis. Microbiome doi:10.1186/s40168-023-01701-z

 

 

 

 

2022
B1
C4

Sponge-symbiont stability in spite of antibiotic-induced microbiome disturbance

Schmittmann L, Rahn T, Busch K, Fraune S, Pita L, Hentschel U. (2022)  Environ. Microbiol. 24: 6392-6410, https://doi.org/10.1111/1462-2920.16249

2022
B1

Harnessing the power of model organisms to unravel coral holobiont complexity

Puntin G., Sweet M, Fraune S., Medina M., Weiss V, Ziegler M (2022)  Microbiol. Mol. Biol. Reviews, 21;86(4):e0005322, https://doi.org/10.1128/mmbr.00053-22

2022
B1

Stability of a dominant sponge-symbiont in spite of antibiotic-induced microbiome disturbance

Schmittmann L, Rahn T, Busch K, Fraune S, Pita L, Hentschel U. Stability of a dominant sponge-symbiont in spite of antibiotic-induced microbiome disturbance (2022)  Environ. Microbiol. 24: 6392-6410, https://doi.org/10.1111/1462-2920.16249

2022
B1
C1
C4

Symbiotic Algae of Hydra viridissima Play a Key Role in Maintaining Homeostatic Bacterial Colonization.

Bathia J, Schröder K, Fraune S, Lachnit T, Rosenstiel P, Bosch TCG (2022) Front. Microbiol. 13:869666. doi: 10.3389/fmicb.2022.869666

2022
B1
Z3

Population differences and host species predict variation in the diversity of host-associated microbes in Hydra

Taubenheim J, Miklós M, Tökölyi J, Fraune S (2022). Front. Microbiol. 13:799333. doi: 10.3389/fmicb.2022.799333

2022
B1
C1
Featured

The role of DNA methylation in genome defense in Cnidaria and other invertebrates

Ying H, Hayward DC, Klimovich A, Bosch TCG, Baldassarre L, Neeman T, Forêt S, Huttley G, Reitzel AM, Fraune S, Ball EE, Miller DJ (2022) Molecular Biology and Evolution, msac018, doi: 10.1093/molbev/msac018

2021
B1

Contribution of maternal and paternal transmission to bacterial colonization in Nematostella vectensis.

Baldassarre L, Levy S, Bar-Shalom R, Steindler L, Lotan T, Fraune S (2021)  Front Microbiol. 12: 726795. doi: 3389/fmicb.2021.726795

2021
B1

Hydra and Curvibacter – an intimate crosstalk at the epithelial interface. In: Cellular Dialogues in the Holobiont.

Minten T, Fraune S (2021)  ed. by Bosch, Thomas C. G. and Hadfield, Michael G.. CRC Press, Boca Raton, Fla., USA, pp. 79-89 ISBN 9780429277375 doi: 1201/9780429277375-4.

2020
B1
C1
Featured

Bacteria- and temperature-regulated peptides modulate beta-catenin signalling in Hydra

Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J, Bosch TCG, Fraune S (2020) PNAS. 117(35):21459-21468. doi: 10.1073/pnas.2010945117

2020
A4
B1

Bdellovibrio and like organisms are predictors of microbiome diversity across diverse host groups.

Johnke J, Fraune S, Bosch TCG, Hentschel U, Schulenburg H (2020) Microbial Ecology. 79: 252–257. doi: 10.1007/s00248-019-01395-7

2019
A1
A2
A3
B1
B2
C1
C2
INF
Z3
Featured

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1

2019
A4
B1
C1
C2
Featured

Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways

Mortzfeld BM*, Taubenheim J*, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019) Nature Communications 10, 3257. doi: 10.1038/s41467-019-11136-6

2019
A2
A4
B1
B2
Featured

Neutrality in the metaorganism

Sieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, Traulsen A (2019) PLoS Biol., DOI: 10.1371/journal.pbio.3000298

2019
A4
B1
B2

Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches

Jaspers C, Fraune S, Consortium of Australian Academy of Science Boden Research Conference Participants, Arnold AE, Miller DJ, Bosch TCG, Voolstra CR (2019) Zoology. doi: 10.1016/j.zool.2019.02.007

2018
A4
B1
C1
Z1

Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.

Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC (2018); Elife 7. pii: e35122. doi: 10.7554/eLife.35122

2018
A3
C1

Carrying capacity and colonization dynamics of Curvibacter in the Hydra host habitat

Wein T, Dagan T, Fraune S, Bosch TCG, Reusch TBH and Hülter NF (2018) Front. Microbiol.,  https://doi.org/10.3389/fmicb.2018.00443

2018
B1

Predicted bacterial interactions affect in vivo microbial colonization dynamics in Nematostella

Domin H, Zurita-Gutiérrez Y, Scotti M, Buttlar J, Hentschel Humeida U and Fraune S  (2018) Frontiers in Microbiology 9, 728, https://doi.org/10.3389/fmicb.2018.00728

2018
A4
B1
C1
Z1

Stem cell transcription factor FoxO controls microbiome resilience in Hydra.

Mortzfeld B M, Taubenheim J,Fraune S, Klimovich A V, Bosch T C G (2018); Front Microbiol., doi: 10.3389/fmicb.2018.00629

2018
A1
A2
A3
A4
B1
B2
C1
Z1

Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?

Bang C, Dagan T, Deines P, Dubilier N, Duschl W J, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Galan P L, Pogoreutz C, Rädecker N, Saad M M, Schmitz R A, Schulenburg H, Voolstra C R, Weiland-Bräuer N, Ziegler M, Bosch T C G (2018); Zoology, doi: 10.1016/j.zool.2018.02.004

2017
A4
B1
C1
Z1

Temperate phages as self-replicating weapons in bacterial competition.

Li XY, Lachnit T, Fraune S, Bosch T C G, Traulsen A, Sieber M (2017); J R Soc Interface, 14(137). doi: 10.1098/rsif.2017.0563

2017
A4
B1
C1
Z1
Featured

A secreted antibacterial neuropeptide shapes the microbiome of Hydra.

Augustin R, Schröder K, Murillo Rincón A P, Fraune S, Anton-Erxleben F, Herbst E M, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar T M, Bosch T C G (2017); Nat Commun., 8(1):698. doi: 10.1038/s41467-017-00625-1

2016
A4
B1
Z2

Emerging Sponge Models of Animal-Microbe Symbioses.

Pita L, Fraune S, Hentschel U (2016); Front Microbiol., 7:2102. doi: 10.3389/fmicb.2016.02102

2016
A4
B1

Using Nematostella vectensis to Study the Interactions between Genome, Epigenome, and Bacteria in a Changing Environment.

Fraune S, Forêt S, Reitzel A M (2016); Front. Mar. Sci., 3:148. doi: 10.3389/fmars.2016.00148

Institutions & Partners