Principal Investigator

Prof. Dr. Andre Franke

Institution

Kiel University
University Hospital Schleswig Holstein
Institute of Clinical Molecular Biology
Genetics & Bioinformatics Lab
Vita

Education/Training

2004 – 2006
PhD work at CAU under supervision of Profs. Stefan Schreiber: “A systematic genome-wide association analysis for inflammatory bowel diseases”

2002 – 2003
Diploma thesis at the laboratory of Prof. Thomas C.G. Bosch at CAU: “Development of a high-throughput screening for identification of developmentally regulated genes in Hydra”

1998 – 2002
Study of Biology and Informatics at CAU

Research Experience/Academic Appointments

Since 2016
W3 professorship of Molecular Medicine

Since 2011
Director of the Institute of Clinical Molecular Biology

2011 – 2016

W2 endowment professorship “Peter Hans-Hofschneider”of the Foundation of Experimental Biomedicine (Zuerich, Switzerland)

2011
Guest scientists at the Broad Institute of MIT and Harvard (Boston, USA) in the group of Mark J. Daly and mentored by Richard S. Blumberg

2008 – 2013
Academic guest professorship at the Medical Faculty, University of Oslo, Norway (Rikshospitalet)

2008 – 2011
W1 junior professorship for Epithelial Barrier Diseases within the DFG Cluster of Excellence “Inflammation at Interfaces”

Important Scientific Prizes/Functions

Since 2012
Spokesperson of the DFG Research Training Group GRK1743/1 “Genes, Environment and Inflammation”

Since 2012
Member of the Steering Committee of “Inflammation at Interfaces”; Leader of Research Area I (Genetics)

2017
Schleswig-Holstein Excellence Chair (8 professors in State selected)

2017
Thannhauser Prize of the DGVS

2012
Ludwig-Demling Research Prize of German Crohn’s and Colitis Foundation (DCCV); 25,000 €

2011
Janssen Prize Dermatology

2009 – 2012
Spokesperson of the young investigators of the Excellence Cluster “Inflammation at Interfaces”

2008
Hensel Prize (100,000 €) for Excellent Research of CAU Kiel

Contact

+49 431 500 15112
+49 431 500 15168
a.franke@mucosa.de
http://www.ikmb.uni-kiel.de/people/scientists/andre-franke https://gepris.dfg.de/gepris/person/118742120

Associated Research Groups

Prof. Dr. Andre Franke
Publications

Publications

Filter by

Year All
2024
C4

The archaeome in metaorganism research, with a focus on marine models and their bacteria–archaea interactions

von Hoyningen-Huene, A. J., Bang, C., Rausch, P., Rühlemann, M., Fokt, H., He, J., Jensen, N., Knop, M., Petersen, C., Schmittmann, L., Zimmer, T., Baines, J. F., Bosch, T. C. G., Hentschel, U., Reusch, T. B. H., Roeder, T., Franke, A., Schulenburg, H., Stukenbrock, E., & Schmitz, R. A. (2024). Frontiers in Microbiology, 15, 1347422. doi: https://doi.org/10.3389/fmicb.2024.1347422

2024
B1

Shaping tiny worlds: Paternal microbiota manipulation influences offspring microbial colonization and development in a sex role-reversed pipefish

Wagner, K. S., Salasc, F., Marten, S. M., & Roth, O. (2024). bioRxiv, 2024-10. doi: https://doi.org/10.1101/2024.10.09.617486

2024
A1

Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics

Marinos, G., Hamerich, I. K., Debray, R., Obeng, N., Petersen, C., Taubenheim, J., Zimmermann, J., Blackburn, D., Samuel, B. S., Dierking, K., Franke, A., Laudes, M., Waschina, S., Schulenburg, H., & Kaleta, C. (2024). Microbiology Spectrum, 12(2), e01144-23. doi: https://doi.org/10.1128/spectrum.01144-23

 

2022
B1.1
B1
Featured

Biodiversity, environmental drivers, and sustainability of the global deep-sea sponge microbiome

Kathrin Busch, Beate M. Slaby, Wolfgang Bach, Antje Boetius, Ina Clefsen, Ana Colaço, Marie Creemers, Javier Cristobo, Luisa Federwisch, Andre Franke, Asimenia Gavriilidou, Andrea Hethke, Ellen Kenchington, Furu Mienis, Sadie Mills, Ana Riesgo, Pilar Ríos, Emyr Martyn Roberts, Detmer Sipkema, Lucía Pita, Peter J. Schupp, Joana Xavier, Hans Tore Rapp & Ute Hentschel (2022) Nature Communications. 13: 5160. doi: 1038/s41467-022-32684-4

2022
A2
C2

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Fazio A, Bordoni D, Kuiper JWP, Franke A, Rosenstiel P. et al. DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon. Nat Commun 13, 6266 (2022). https://doi.org/10.1038/s41467-022-33844-2

 

2021
A2

Ecology impacts the decrease of Spirochaetes and Prevotella in the fecal gut microbiota of urban humans

Thingholm LB, Bang C, Rühlemann MC, Starke A, Sicks F, Kaspari V, Jandowsky A, Frölich K, Ismer G, Bernhard A, Bombis C, Struve B, Rausch P, Franke A (2021) BMC Microbiol. 21:276. doi: 10.1186/s12866-021-02337-5

2021
A2
Featured

Primate phageomes are structured by superhost phylogeny and environment.

Gogarten, JF, Rühlemann M, Archie E, Tung J, Akoua-Koffi C, Bang C, Deschner T, Muyembe-Tamfun J-J, Robbins MM, Schubert G, Surbeck M, Wittig RM, Zuberbühler K, Baines JF, Franke A, Leendertz FH, Calvignac-Spencer S, PNAS. 118 (15) e2013535118. doi: 10.1073/pnas.2013535118

2021
A2
Featured

Large-scale association analyses identify host factors influencing human gut microbiome composition.

Kurilshikov A, Medina-Gomez C, Bacigalupe R,…Rühlemann MC,…Bang C,…Franke A,… et al. (2021) Nat Genet 53:156–165. doi: 10.1038/s41588-020-00763-1

2021
A2
INF
Featured

Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.

Rühlemann MC, Hermes BM, Bang C, Doms S, Moitinho-Silva L, Thingholm LB, Frost F, Degenhardt F, Wittig M, Kässens J, Weiss FU, Peters A, Neuhaus K, Völker U, Völzke H, Homuth G, Weiss S, Laudes M, Lieb W, Haller D, Lerch MM, Baines JF, Franke A (2021) Nat Genet. 53, 147–155. doi: 10.1038/s41588-020-00747-1

2020
A2
Featured

Genome-wide associations of human gut microbiome variation and implications for causal inference analyses

Hughes DA, Bacigalupe R, Wang J, Rühlemann MC, Tito RY, Falony G, Rymenans L, Verspecht C, Ring S, Franke A, Wade KH, Timpson NJ, Raes J (2020) Nat Microbiol 5, 1079–1087. doi: 10.1038/s41564-020-0743-8
2020
A2

A disease‐specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis

Liwinski T, Casar C, Ruehlemann MC, Bang C, Sebode M, Hohenester S, Denk G, Lieb W, Lohse AW, Franke A, Schramm C (2020) Aliment Pharmacol Ther. 51(12):1417-1428. doi: 10.1111/apt.15754
2020
A2
A3
Featured

A fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition

Seybold H, Demetrowitsch TJ, Hassani M A, Szymczak S, Reim E, Haueisen J, Lübbers L, Rühlemann M, Franke A, Schwarz k, H. Stukenbrock E (2020) Nature Communications. 11(1):1910. doi: 10.1038/s41467-020-15633-x

2020
A2
Featured

Alterations of the bile microbiome in primary sclerosing cholangitis

Liwinski T, Zenouzi R, John C, Ehlken H, Rühlemann MC, Bang C,  Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JH, Rösch T, Lohse AW, Heeren J, Franke A, Schramm C (2020) Gut 69 (4), 665-672 doi: 10.1136/gutjnl-2019-318416
2019
A1
A2
A3
B1
B2
C1
C2
INF
Z3
Featured

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1

2019
Featured

Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy

Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C, Cabreiro F (2019) Cell 178(6): 1299–1312. doi: 10.1016/j.cell.2019.08.003

2019
A2

Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis

Rühlemann M, Liwinski T, Heinsen F-A, Bang C, Zenouzi R, Kummen M, Thingholm L, Tempel M, Lieb W, Karlsen T, Lohse A, Hov J, Denk G, Lammert F, Krawczyk M, Schramm C, Franke A (2019) Aliment Pharmacol Ther. 1-10. doi: 10.1111/apt.15375

2019
A2
Featured

Alterations of the bile microbiome in primary sclerosing cholangitis

Liwinski T, Zenouzi R, John C, Ehlken H, Rühlemann MC, Bang C, Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen TH, Hov JR, Rösch T, Lohse AW, Heeren J, Franke A, Schramm C (2019) Gut 0:1–8. doi:10.1136/gutjnl-2019-318416

2018
A2
C2

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018) Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5.
2018
A2
C2
INF
Z3

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.

Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018); Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5

2018
A2
B1
INF
Z2

The sponge holobiont in a changing ocean: from microbes to ecosystems.

Pita L, Rix L, Slaby B M, Franke A, Hentschel U (2018); Microbiome, 6(46). doi: 10.1186/s40168-018-0428-1

2018
A2

Epidermal lipid composition, barrier integrity, and eczematous inflammation are associated with skin microbiome configuration

Baurecht H, Rühlemann M, Rodríguez E, Thielking F, Harder I, Erkens AS, Stölzl D, Ellinghaus E, Hotze M, Lieb W, Wang S, Heinsen FA, Franke A, Weidinger S (2018) J ALLERGY CLIN IMMUN . doi: 10.1016/j.jaci.2018.01.019

2018
A2
C2
INF
Z3

The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany.

Häsler R, Kautz C, Rehman A, Podschun R, Gassling V, Brzoska P, Sherlock J, Gräsner J T, Hoppenstedt G, Schubert S, Ferlinz A, Lieb W, Laudes M, Heinsen F A, Scholz J, Harmsen D, Franke A, Eisend S, Kunze T, Fickenscher H, Ott S, Rosenstiel P, Schreiber S (2018); Microbiome., 6(1):37. doi: 10.1186/s40168-018-0414-7

2017
A2
Z3

Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.

Rühlemann M C, Degenhardt F, Thingholm L B, Wang J, Skiecevičienė J, Rausch P, Hov J R, Lieb W, Karlsen T H, Laudes M, Baines J F, Heinsen F A, Franke A (2017); Gut Microbes., 8:55. doi: 10.1080/19490976.2017.1356979

2016
A2
C2
INF
Z3
Featured

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

Wang J, Thingholm L B, Skiecevičienė J, Rausch P, Kummen M, Hov J R, Degenhardt F, Heinsen F A, Rühlemann M C, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge R K, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan W H, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D’Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall H U, Lieb W, Nöthlings U, Karlsen T H, Baines J F, Franke A (2016); Nat Genet., 48(11):1396-1406. doi: 10.1038/ng.3695

Institutions & Partners