Principal Investigator

Prof. Dr. Christoph Kaleta

Institution

Kiel University
University Hospital Schleswig Holstein
Institute for Experimental Medicine
Medical Systems Biology Lab
Vita

Education/Training

2009 – 2010
PhD degree at University of Jena, Germany

2003 – 2008
Studies in Bioinformatics, University of Jena, Germany

Research Experience/Academic Appointments

Since 2014
Professor of Medical Systems Biology (W2), Christian-Albrechts University Kiel

2014
Associate professor of Computational Biology, University of Southern Denmark, Denmark

2011 – 2014
Assistant professor of Theoretical Systems Biology, University of Jena

2008 – 2011
Research scientist, University of Jena

Important Scientific Prizes/Functions

Since 2017
Head of the Institute of Experimental Medicine, CAU Kiel

Since 2014
Head of Clusterlab IX (“Theoretical Biology”) of the Excellence Cluster Inflammation at Interfaces

Since 2014
Steering committee of the Excellence Cluster Inflammation at Interfaces

Since 2014
Member of the Editorial Board of Metabolites

Since 2014
Guest Editor for PLoS Computational Biology

2013
German-Israeli Foundation Young Investigator Award

2010
PhD price of the School of Biology and Pharmacy of the University of Jena

Contact

+49 431 500 30340
+49 431 500 30344
c.kaleta@iem.uni-kiel.de
https://www.iem.uni-kiel.de/de/medizinische-systembiologie https://gepris.dfg.de/gepris/person/214422033?context=person&task=showDetail&id=214422033&

Associated Research Groups

Prof. Dr. Christoph Kaleta
Publications

Publications

Filter by

Year All
2024
A1
A4

Gut-associated functions are favored during microbiome assembly across a major part of C. elegans life

Zimmermann, J., Piecyk, A., Sieber, M., Petersen, C., Johnke, J., Moitinho-Silva, L., Künzel, S., Bluhm, L., Traulsen, A., Kaleta, C., & Schulenburg, H. (2024). Mbio, 15(5), e00012-24. doi: https://doi.org/10.1128/mbio.00012-24

2024
A1

Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans

Peters, L., Drechsler, M., Pees, B., Angelidou, G., Salzer, L., Moors, K. A., Paczia, N., Schulenburg, H., Shi, Y. M.,  Kaleta, C., Witting, M., Bode, H. B., & Dierking, K. (2024). bioRxiv, 2024-02. doi: https://doi.org/10.1101/2024.02.06.579051

2024
A1

Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics

Marinos, G., Hamerich, I. K., Debray, R., Obeng, N., Petersen, C., Taubenheim, J., Zimmermann, J., Blackburn, D., Samuel, B. S., Dierking, K., Franke, A., Laudes, M., Waschina, S., Schulenburg, H., & Kaleta, C. (2024). Microbiology Spectrum, 12(2), e01144-23. doi: https://doi.org/10.1128/spectrum.01144-23

 

2023
A1
C2

Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model.

Pfefferkorn RM, Mortzfeld BM, Fink C, von Frieling J, Bossen J, Esser D, Kaleta C, Rosenstiel P, Heine H, Roeder T (2023) Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model. Aging&Disease in press.

2023
A1
A4
INF

Gut-associated functions are favored during microbiome assembly across C. elegans life

Zimmermann J*, Piecyk A*, Sieber M, Petersen C, Johnke J, Moitinho-Silva L, Künzel S, Bluhm L, Traulsen A, Kaleta C, Schulenburg H (2023) Gut-associated functions are favored during microbiome assembly across C. elegans life. bioRxiv doi:10.1101/2023.03.25.534195. *Shared first authorship.

2023
A1
A2
B2
B4
Z2
Z3

Closely related Bacteroides of the murine intestinal microbiota affect each other’s growth positively or negatively

Hanna Fokt, Gabija Sakalyte, Rahul Unni, Mohammad Abukhalaf, Liam Cassidy, Georgios Marinos, Maxime Godfroid, Birhanu M Kinfu, Ruth A Schmitz, Christoph Kaleta, Andreas Tholey, John F Baines, Tal Dagan, Daniel Unterweger (2023) BioRxiv doi: https://doi.org/10.1101/2023.03.05.530569
2023
A1
B1
INF
Z2

Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis

Domin H, Zimmermann J, Taubenheim J, Fuentes Reyes G, Saueressig L, Prasse D, Höppner M, Schmitz RA, Hentschel U, Kaleta C, Fraune S (2023) Sequential host-bacteria and bacteria-bacteria interactions determine the microbiome establishment of Nematostella vectensis. Microbiome doi:10.1186/s40168-023-01701-z

 

 

 

 

2021
A1
Featured

In vitro interaction network of a synthetic gut bacterial community.

Weiss AS, Burrichter AG, Durai Raj AC, von Strempel A, Meng C, Kleigrewe K, Münch PC, Rössler L, Huber C, Eisenreich W, Jochum LM, Göing S, Jung K, Lincetto C, Hübner J, Marinos G, Zimmermann J, Kaleta C, Sanchez A, Stecher B (2021)  ISME J. doi: 1038/s41396-021-01153-z

2021
A1
C2
Z2
Featured

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.

Hinrichsen F, Hamm J, Westermann M, Schröder L, Shima K, Mishra N, Walker A, Sommer N, Klischies K, Prasse D, Zimmermann J, Kaiser S, Bordoni D, Fazio A, Marinos G, Laue G, Imm S, Tremaroli V, Basic M, Häsler R, Schmitz RA, Krautwald S, Wolf A, Stecher B, Schmitt-Kopplin P, Kaleta C, Rupp J, Bäckhed F, Rosenstiel P, Sommer F (2021) Cell Metab 33(12):2355-2366.e8. doi: 1016/j.cmet.2021.11.004

2021
A1
Featured

Metabolic dissimilarity determines the establishment of cross-feeding interactions in bacteria

Giri S, Oña L, Waschina S, Shitut S, Yousif G, Kaleta C, Kost C (2021) Curr Biol. S0960-9822(21)01408-1. doi: 1016/j.cub.2021.10.019.

2021
A1
Featured

gapseq: informed prediction of bacterial metabolic pathways and reconstruction of accurate metabolic models

Zimmermann J, Kaleta C, Waschina S (2021) Genome Biol. 22(81):1-35. doi: 10.1186/s13059-021-02295-1

2020
A1

Defining the nutritional input for genome-scale metabolic models: a roadmap

Marinos G, Kaleta C, Waschina S (2020) PLOS ONE 15(8): e0236890. doi: 10.1371/journal.pone.0236890

2020
A1

CeMbio – The Caenorhabditis elegans microbiome resource

Dirksen P, Assié A, Zimmermann J, Zhang F, Tietje A-M, Arnaud Marsh S, Félix M-A, Shapira M, Kaleta C, Schulenburg H, Samuel B (2020) G3. 10(9): 3025–3039. doi: 10.1534/g3.120.401309
2020
A1
A4
INF
Featured

The functional repertoire contained within the native microbiota of the model nematode Caenorhabditis elegans

Zimmermann J*, Obeng N*, Yang W, Pees B, Petersen C, Waschina S, Kissoyan KAB, Aidley J, Hoeppner MP, Bunk B, Spröer C, Leippe M, Dierking K, Kaleta C*, Schulenburg H* (2019) ISME J. 14: 26–38. * Shared first or senior authorship  doi: 10.1038/s41396-019-0504-y

2019
Featured

Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy

Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C, Cabreiro F (2019) Cell 178(6): 1299–1312. doi: 10.1016/j.cell.2019.08.003

2019
A1
A4
INF
Z3

The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life

Yang W#, Petersen C#, Pees B#, Zimmermann J, Waschina S, Dirksen P, Rosenstiel P, Tholey A, Leippe M, Dierking K, Kaleta C*, Schulenburg H*.  Front Microbiol. 10:1793. # Equal contribution as first authors, * Equal contribution as senior authors doi: 10.3389/fmicb.2019.01793.

2019
A1
Featured

Natural C. elegans microbiota protects against infection via production of a cyclic lipopeptide of the viscosin group

Kohar Kissoyan, Moritz Drechsler, Eva-Lena Stange, Johannes Zimmermann, Christoph Kaleta, Helge Bode und Katja Dierking (2019)  Current Biology. DOI: 10.1016/j.cub.2019.01.050

2018
INF

Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants.

Graspeuntner S, Waschina S, Künzel S, Twisselmann N, Rausch TK, Cloppenborg-Schmidt K, Zimmermann J, Viemann D, Herting E, Göpel W, Baines JF, Kaleta C, Rupp J, Härtel C, Pagel J (2018) Clin Infect Dis. doi: 10.1093/cid/ciy882

Institutions & Partners