Principal Investigator, Steering Committee

Prof. Dr. Philip Rosenstiel

Institution

Kiel University
University Hospital Schleswig Holstein
Institute of Clinical Molecular Biology
Systems Immunology Lab
Vita

Education/Training

2003
Dissertation (Dr. med.) “summa cum laude”

2001
Final Examination Medicine (MD)

1994 – 2001
Scholarship of the Studienstiftung des Deutschen Volkes

1994 – 2001
Study of Medicine at the Christian-Albrechts-Universität zu Kiel, Germany and Tufts University, Boston, USA

Research Experience/Academic Appointments

Since 2016
Professor of Molecular Medicine (W3), Kiel University

Since 2012
Director, Institute of Clinical Molecular Biology, Kiel University

2016
Offer Chair position at Universite Poincare and INSERM 1256, Nancy (declined)

2012 – 2016
Professor of Molecular Medicine (W2), Kiel University

2007 – 2012
Professor of Molecular and Marine Medicine (W2), IKMB, Kiel University

2005 – 2007
Postdoctoral fellow (delegated), Max Planck Institute for Molecular Genetics, Berlin (Prof. Dr. H. Lehrach)

2004 – 2005
Group leader Cell Biology, Institute of Clinical Molecular Biology (Prof. Dr. S. Schreiber), Kiel University

2001 – 2006
Training in Internal Medicine, 1st Medical Department, University Hospital Kiel

2001 – 2004
Postdoctoral fellow in the 1st Medical Department, University Hospital Kiel and the Institute of Clinical Molecular Biology, Kiel University

1997 -1998
BMEP research fellowship at the Jackson Laboratory, Bar Harbor, USA (P. Nishina and J. Naggert), and St. Elisabeth Hospital Boston, USA (J. Isner)

1996 – 2002
MD thesis at the Institute of Anatomy (Prof. Dr. J. Sievers), Kiel University

Important Scientific Prizes/Functions

Since 2017
Elected speaker of the project committee of the national e:Med BMBF systems medicine program

Since 2017
Member of the Steering board of the International Human Epigenome Consortium (IHEC)

Since 2017
Schleswig-Holstein Excellence Chair

Since 2017
Coordinator of the H2020 SYSCID consortium

Since 2008
Member of the steering board Cluster of Excellence Inflammation at Interfaces

2004
Prize for the best doctoral thesis of the Medical faculty of the University of Kiel (‘Dissertationspreis 2003’)

2003
Hensel-Research Prize of the Christian-Albrechts-University Kiel

2001
Recipient of the Graduate stipend of the “Novartis Stiftung für therapeutische Forschung”

Contact

+49 431 500 15105
+49 431 500 15168
p.rosenstiel@mucosa.de
http://www.ikmb.uni-kiel.de/people/scientists/philip-rosenstiel https://gepris.dfg.de/gepris/person/1828741

Associated Research Groups

Prof. Dr. Philip Rosenstiel
Publications

Publications

Filter by

Year All
2023
A1
C2

Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model.

Pfefferkorn RM, Mortzfeld BM, Fink C, von Frieling J, Bossen J, Esser D, Kaleta C, Rosenstiel P, Heine H, Roeder T (2023) Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model. Aging&Disease in press.

2022
B1
C1
C4

Symbiotic Algae of Hydra viridissima Play a Key Role in Maintaining Homeostatic Bacterial Colonization.

Bathia J, Schröder K, Fraune S, Lachnit T, Rosenstiel P, Bosch TCG (2022) Front. Microbiol. 13:869666. doi: 10.3389/fmicb.2022.869666

2022
A2
C2

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

Fazio A, Bordoni D, Kuiper JWP, Franke A, Rosenstiel P. et al. DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon. Nat Commun 13, 6266 (2022). https://doi.org/10.1038/s41467-022-33844-2

 

2021
A1
C2
Z2
Featured

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.

Hinrichsen F, Hamm J, Westermann M, Schröder L, Shima K, Mishra N, Walker A, Sommer N, Klischies K, Prasse D, Zimmermann J, Kaiser S, Bordoni D, Fazio A, Marinos G, Laue G, Imm S, Tremaroli V, Basic M, Häsler R, Schmitz RA, Krautwald S, Wolf A, Stecher B, Schmitt-Kopplin P, Kaleta C, Rupp J, Bäckhed F, Rosenstiel P, Sommer F (2021) Cell Metab 33(12):2355-2366.e8. doi: 1016/j.cmet.2021.11.004

2021
A1
INF

The genetics of gene expression in a Caenorhabditis elegans multiparental recombinant inbred line population.

Snoek BL, Sterken MG, Nijveen H, Volkers RJM, Riksen J, Rosenstiel PC, Schulenburg H, Kammenga JE. (2021) G3 (Bethesda). 11(10):jkab258. doi: 10.1093/g3journal/jkab258.

2021
A1

The effects of nested miRNAs and their host genes on immune defense against Bacillus thuringiensis infection in Caenorhabditis elegans.

Zárate-Potes A, Yang W, Andresen B, Nakad B, Haase D, Rosenstiel P, Dierking K*, Schulenburg H* (2021) Dev Comp Immunol. 123:104144 doi: 10.1016/j.dci.2021.104144  *Shared senior authorship.

2020
C2

Nutritional targeting of the microbiome as potential 3 therapy for malnutrition and chronic inflammation

Schröder L , Kaiser S , Flemer B , Hamm J , Hinrichsen F , Bordoni D , Rosenstiel P , Sommer F (2020) Nutrients. 12(10):E3032. doi: 10.3390/nu12103032.

2020
C2

A high-fat diet induces a microbiota-dependent increase in stem cell activity in the Drosophila intestine.

von Frieling J, Faisal MN, Sporn F, Pfefferkorn R, Nolte SS, Sommer F, Rosenstiel P, Roeder T (2020) PLoS Genet. 16(5):e1008789. doi: 10.1371/journal.pgen.1008789

2020
A2
C2
Z3

NOD2 influences trajectories of intestinal microbiota recovery after antibiotic perturbation

Moltzau Anderson J, Lipinski S, Sommer F, Pan W-H, Boulard O, Rehman A, Falk-Paulsen M, Stengel ST, Aden K, Häsler R, Bharti R, Künzel S, Baines JF, Chamaillard M, Rosenstiel P (2020) Cell Mol Gastroenterol Hepatol. 10(2): 365-389. doi: 10.1016/j.jcmgh.2020.03.008

2020
C2
Featured

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.

Cader MZ, de Almeida Rodrigues RP, West JA, Sewell GW, Md-Ibrahim MN, Reikine S, Sirago G, Unger LW, Iglesias-Romero AB, Ramshorn K, Haag LM, Saveljeva S, Ebel JF, Rosenstiel P, Kaneider NC, Lee JC, Lawley TD, Bradley A, Dougan G, Modis Y, Griffin JL, Kaser A (2020) Cell. 180(2):278-295.e23. doi:10.1016/j.cell.2019.12.017

2020
C2
Featured

Adrenergic signaling in muscularis macrophages limits infection-induced neuronal loss.

Matheis F, Muller PA, Graves CL, Gabanyi I, Kerner ZJ, Costa-Borges D, Ahrends T, Rosenstiel P, Mucida D (2020) Cell. 180(1): 64-78.e16. doi:10.1016/j.cell.2019.12.002

2020
C2

Autophagy of intestinal epithelial cells inhibits colorectal carcinogenesis induced by colibactin-producing Escherichia coli in Apc(Min/+) mice.

Lucas C, Salesse L, Thi Hoang MH, Bonnet M, Sauvanet P, Larabi A, Godfraind C, Gagnière J, Pezet D, Rosenstiel P, Barnich N, Bonnet R, Dalmasso G, Nguyen HTT (2020) Gastroenterology. 158(5): 1373-1388. doi:10.1053/j.gastro.2019.12.026

2019
B2
INF
Z3

Host-microbe interactions in the chemosynthetic Riftia pachyptila symbiosis

Hinzke T, Kleiner M, Breusing C, Felbeck H, Häsler R, Sievert SM, Schlüter R, Rosenstiel P, Reusch TBH, Schweder T, Markert S (2019) mBio 10:6, e02243-19. doi: 10.1128/mBio.02243-19

2019
C2
Featured

Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology

Sonner JK*, Keil M*, Falk-Paulsen M*, Mishra N, Rehman A, Kramer M, Deumelandt K, Röwe J, Sanghvi K, Wolf L, von Landenberg A, Wolff H, Bharti R, Oezen I, Lanz TV, Wanke F, Tang Y, Brandao I, Mohapatra SR, Epping L, Grill A, Röth R, Niesler B, Meuth SG, Opitz CA, Okun JG, Reinhardt C, Kurschus FC, Wick W, Bode HB, Rosenstiel P*, Platten M* (2019) Nat Commun. 10(1):4877. doi: 10.1038/s41467-019-12776-4. *shared first or last authorship

2019
C2

The microbiota promotes arterial thrombosis in low-density lipoprotein receptor-deficient mice

Kiouptsi K#, Jäckel S#, Pontarollo G#, Grill A, Kuijpers MJE, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der Vorst EPC#, Döring Y#, Reinhardt C (2019) mBio. 10(5). doi: 10.1128/mBio.02298-19. # Contributed equally

2019
A1
C2
Featured

Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles

Lipinski S, Pfeuffer S, Arnold P, Treitz C, Aden K, Ebsen H, Falk-Paulsen M, Gisch N, Fazio A, Kuiper J, Luzius A, Billmann-Born S, Schreiber S, Nuñez G, Beer HD, Strowig T, Lamkanfi M, Tholey A, Rosenstiel P (2019) EMBO J. 38(20) doi: 10.15252/embj.2018101266.

2019
A4
B1
C2
Featured

A phage protein aids bacterial symbionts in eukaryote immune evasion

Jahn MT, Arkhipova K, Markert SM, Stigloher C, Lachnit T, Pita L, Kupczok A, Ribes M, Stengel ST, Rosenstiel P, Dutilh BE, Hentschel U (2019) Cell Host & Microbe, doi: 10.1016/j.chom.2019.08.019

2019
A1
A2
A3
B1
B2
C1
C2
INF
Z3
Featured

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen F-A, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF (2019) Microbiome, doi: 10.1186/s40168-019-0743-1

2019
A1
A4
INF
Z3

The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life

Yang W#, Petersen C#, Pees B#, Zimmermann J, Waschina S, Dirksen P, Rosenstiel P, Tholey A, Leippe M, Dierking K, Kaleta C*, Schulenburg H*.  Front Microbiol. 10:1793. # Equal contribution as first authors, * Equal contribution as senior authors doi: 10.3389/fmicb.2019.01793.

2019
A4
B1
C1
C2
Featured

Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways

Mortzfeld BM*, Taubenheim J*, Klimovich AV, Fraune S, Rosenstiel P, Bosch TCG (2019) Nature Communications 10, 3257. doi: 10.1038/s41467-019-11136-6

2019
A1

aFold – using polynomial uncertainty modelling for differential gene expression estimation from RNA sequencing data

Yang W, Rosenstiel P, Schulenburg H (2019) BMC Genomics, 20:364, 1-17. doi: 10.1186/s12864-019-5686-1

2019
A1

A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life-history traits

Snoek BL, Volkers RJM, Nijveen H, Petersen C, Dirksen P, Sterken MG, Nakad R, Riksen J, Rosenstiel P, Stastna JJ, Braeckman BP, Harvey SC, Schulenburg H*, Kammenga JE* (2019) BMC Biol. 17:24. * Shared senior authorship doi: 10.1186/s12915-019-0642-8

2019
C2
Featured

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

Grootjans J*, Krupka N*, Hosomi S*, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan G-C, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg, RS (2019) Science. 363(6430): 993–998. doi: 10.1126/science.aat7186

2018
C2
Z3
Featured

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P (2018); Gastroenterology. pii: jem.20171029. doi: 10.1084/jem.20171029

2018
A2
C2

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018) Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5.
2018
C2
Z3

A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention.

Prange R, Thiedmann M, Bhandari A, Mishra N, Sinha A, Häsler R, Rosenstiel P, Uliczka K, Wagner C, Yildirim AÖ, Fink C, Roeder T (2018); Aging (Albany NY). 10(8):2122-2135. doi: 10.18632/aging.101536

2018
A4
C1
C2
Z1
Z3

Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy

Von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Thomas C. G. Bosch TCG, Roeder T, P Rosenstiel P, Sommer F (2018); Front. Microbiol. doi: 10.3389/fmicb.2018.02020

2018
C2
Z3
Featured

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.

Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW (2018); Nature 560(7719):489-493. doi: 10.1038/s41586-018-0507-2

2018
A2
C2
INF
Z3

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development.

Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P (2018); Genome Med. 10(1):27. doi: 10.1186/s13073-018-0534-5

2018
A2
C2
INF
Z3

The antibiotic resistome and microbiota landscape of refugees from Syria, Iraq and Afghanistan in Germany.

Häsler R, Kautz C, Rehman A, Podschun R, Gassling V, Brzoska P, Sherlock J, Gräsner J T, Hoppenstedt G, Schubert S, Ferlinz A, Lieb W, Laudes M, Heinsen F A, Scholz J, Harmsen D, Franke A, Eisend S, Kunze T, Fickenscher H, Ott S, Rosenstiel P, Schreiber S (2018); Microbiome., 6(1):37. doi: 10.1186/s40168-018-0414-7

2017
C2
Z3
Featured

The resilience of the intestinal microbiota influences health and disease.

Sommer F, Anderson J M, Bharti R, Raes J, Rosenstiel P (2017); Nat Rev Microbiol., doi: 10.1038/nrmicro.2017.58

2017
A1
C2
Z3
Featured

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection. Gastroenterology.

Ott S J, Waetzig G H, Rehman A, Moltzau-Anderson J, Bharti R, Grasis J A, Cassidy L, Tholey A, Fickenscher H, Seegert D, Rosenstiel P, Schreiber S (2017); Gastroenterology, 152(4):799-811.e7. doi: 10.1053/j.gastro.2016.11.010

2016
C2
Z3
Featured

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects.

Daillère R, Vétizou M, Waldschmitt N, Yamazaki T, Isnard C, Poirier-Colame V, Duong C P, Flament C, Lepage P, Roberti M P, Routy B, Jacquelot N, Apetoh L, Becharef S, Rusakiewicz S, Langella P, Sokol H, Kroemer G, Enot D10, Roux A, Eggermont A, Tartour E, Johannes L, Woerther P L, Chachaty E, Soria J C, Golden E, Formenti S, Plebanski M, Madondo M, Rosenstiel P, Raoult D, Cattoir V, Boneca I G, Chamaillard M, Zitvogel L (2016); Immunity., 45(4):931-943. doi: 10.1016/j.immuni.2016.09.009

2016
A2
C2
INF
Z3
Featured

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

Wang J, Thingholm L B, Skiecevičienė J, Rausch P, Kummen M, Hov J R, Degenhardt F, Heinsen F A, Rühlemann M C, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge R K, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan W H, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D’Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall H U, Lieb W, Nöthlings U, Karlsen T H, Baines J F, Franke A (2016); Nat Genet., 48(11):1396-1406. doi: 10.1038/ng.3695

2016
C2
Z3

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.

Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna J L, Kempster S L, Blumberg R S, Schreiber S, Becher B, Chamaillard M, Kaser A, Rosenstiel P (2016); Cell Rep., 16(8):2208-18. doi: 10.1016/j.celrep.2016.07.054

2016
A1
A4
C2
Z3

The native microbiome of the nematode Caenorhabditis elegans: Gateway to a new host-microbiome model.

Dirksen P, Marsh SA, Braker I, Heitland N, Wagner S, Nakad R, Mader S, Petersen C, Kowallik V, Rosenstiel P C, Felix M A, Schulenburg H (2016); BMC Biology, 14:38. doi:10.1186/s12915-016-0258-1

Institutions & Partners